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Younger patients who achieve substantial weight loss and demonstrate capacity for sustained dietary and exercise changes may be candidates for medication discontinuation with close monitoring

The drug regulator has asked the state authorities to ensure that manufacture/import, distribution, retail/wholesale sales, and dispensing occur only through authorised channels and strictly in line with approved indications and labelling, in an advisory dated March 27

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Access to food must be limited to ensure low caloric intake, considering that children with PWS require 20-30% less energy intake than healthy children of the same age (193)