Iron overload increases ferritin levels and decreases RUNX2 levels in BMSCs, causing irregular morphological changes, significantly reducing their activity, and inhibiting osteogenic differentiation, while melatonin therapy could reverse this process and promote osteogenic differentiation of BMSCs
On the other hand, a single dose of 7 to 10 grams of acetaminophen (14 to 20 extra-strength tablets) can cause liver injury in the average healthy adult
Paoli, Cenci, & Grimaldi, 2011
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