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In a large blinded trial of hyaluronic acid filler for infraorbital hollows, 87.4% of treated patients achieved at least a one-point improvement at Month 3 versus 17.7% in controls, with many results maintained to 12 months or longer

The most commonly reported side effects in clinical trials include: Nausea Vomiting Diarrhea Constipation Most of these symptoms were mild to moderate and tended to improve over time as the body adjusted to the medication, especially when doses were increased gradually