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doi:10.15420/ecr.2020.52 21

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GLP-1 Origin Initially, it was hypothesized that GLP-1 was derived from proglucagon, a 158-amino-acid precursor, specifically from the N-terminal region of the major proglucagon fragment (MPGF)

GLP-1 is an incretin hormone that is secreted in response to food intake, and it exerts multiple actions conducive to glycemic control, including enhancing glucose-dependent insulin secretion, suppressing glucagon release, and delaying gastric emptying [39]