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TMAO is an independent risk factor of cardiovascular morbidity and mortality in patients with established IHD or CKD 18,19 with accumulating evidence suggesting direct causal effects 47

Both GLP-1 and GIP have been shown to regulate appetite and enhance memory formation with a high expression of GIP in neurons within the hippocampus, olfactory bulb, and Purkinje cells of the cerebellum [100]