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20 WuTDuanYJiangJGuTZhangPBiY

Understanding GLP-1 Medications and Muscle Loss Challenges GLP-1 receptor agonists work by mimicking the incretin hormone GLP-1, which naturally regulates blood sugar and appetite

doi: 10.1038/ismej.2014.63 106 ScazzocchioB.MinghettiL.DArchivioM

The inactive structure of GLP-1R presented here aligns nicely with a possible role of the GLP-1R ECD as a negative regulator of GLP-1R, although, in contrast to GCGR, we and others have failed to identify mutations in the ECD/ECL interface that increase basal activity of GLP-1R