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Within 120 days of discontinuation, participants regained an average of 25% of their lost weight

DOI: 10.1152/japplphysiol.00945.2010

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Moreover, IGF-related molecular mechanisms not only play a role in tumor cells but also affect other nontumor cell components in the microenvironment, such as fibroblasts, macrophages and T cells, demonstrating that targeting IGFs alone cannot completely inhibit tumor growth and progression