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For heart disease Another significant benefit of berberine is its protection against heart disease.22 While we dont know for sure if it can stop heart failure, we do know that it can decrease the likelihood of arrhythmias, atherosclerosis, abdominal aortic aneurysms, cardiac hypertrophy (a step toward heart failure), ischemic heart disease, and strokes.23 Furthermore, berberine plays a role in decreasing total cholesterol, LDL cholesterol, and blood triglycerides while increasing HDL (good) cholesterol.24 25 It also lowers high blood pressure, supporting good heart health from multiple angles

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For example, the regulation of 5-HT levels in the gut is significantly improved by the presence of a specific gut microbiota, which has an impact on general mental health and cognition [276]

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