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Activation of the GLP 1 receptor improves insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety

It's always worth discussing an individual target with your dietitian or GP

As First-Line Treatment Guidelines increasingly support GLP-1 agonists as first-line treatment alongside or instead of metformin: When to consider first-line GLP-1: Established cardiovascular disease High cardiovascular risk Significant obesity (BMI 35+) Strong desire for weight loss Insurance coverage available Traditional metformin-first approach: Lower cost without insurance Decades of safety data Effective for many patients Can add GLP-1 later if needed For many patients, starting with a GLP-1 medication rather than metformin provides superior comprehensive benefit

Maisch, Ammerbuch, Germany) was used