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A number of agents have been shown to reduce lipofuscin accumulation, including anti-helminthic flubendazole [65] and zinc [66] in human retinal pigment epithelium, rapamycin in animal cardiomyocytes [67] and murine hepatocytes [68]

Compromise on any of those, and the entire synergistic model falls apart

So in general, there is a very nice effect, good effect on the vascular system, and of course, the vascular system is common for the entire body, so the kidneys and the liver and the heart and what have you, everything, also the brain

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