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In clinical trials of once-daily or BID GLP-1 receptor agonists (liraglutide, lixisenatide, or exenatide BID), mean changes in body weight were 2.1 to 2.9 kg for monotherapy and +0.3 to 3.6 kg in combination with oral antihyperglycemic therapies (13,14,18)

However, a systematic, mechanism-based understanding of how its natural products combat renal fibrosis is conspicuously absent

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These receptors play an important role in metabolism and appetite regulation