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Refrigeration slows further degradation, but it cannot restore potency that has already been lost

By staying below the smallest available commercial dose and extending dosing intervals to 10, 14, 21, or 28 days, providers can deliver meaningful metabolic benefit with dramatically better tolerability and adherence

Enrolled patients were divided into two groups

With this rationale, a study used the IMS Centre for Outcomes Research and Effectiveness (CORE) Diabetes Model (a nonproduct-specific diabetes policy analysis tool that performs real-time simulations developed by IMS Health, Danbury, CT, USA) to examine the impact of improved glycemic control in patients with T2D [62]