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Based on the electron configuration of transition metals, cytosolic copper forms various complexes, which constitute proteins such as albumin and ceruloplasmin for transportation among organs and tissues or serve as cofactors for key metabolic enzymes in physiological responses [130, 131]

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The samples were treated with H2O2 (0.1 to 1 mM) for 4 to 24 h, and OS damage was assessed by immunohistochemistry for 8-OHdG and 4-HNE, which were present at higher levels in POP patients