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In preclinical models, catestatin exhibits anti-inflammatory, antihypertensive, and metabolic effects, and reduced circulating levels have been associated with hypertension, obesity, and insulin resistance (Mahata et al., 1997)

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This finding is particularly significant, as CAP is known to bind to the transmembrane domains of TRPV1 channels 60 , suggesting that exendin 939 is a selective and potent antagonist for pain relief without competitively displacing CAP at its binding site

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