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A GLP-1 (glucagon-like peptide-1) medication can help someone lose weight when nothing else has worked, as it addresses multiple biological factors that often sabotage weight loss efforts, especially those beyond willpower or lifestyle changes alone

About the Author Dr Varun Harish is a Specialist Plastic, Reconstructive and Burns Surgeon in Sydney and a Fellow of the Royal Australasian College of Surgeons (FRACS) whose clinical practice includes abdominal wall surgery and post-pregnancy body contour surgery

Excessive activation of MR leads to increased expression of pro-inflammatory and profibrotic genes, and generation of reactive oxygen species, contributory to tubular inflammation and fibrosis ( Overall, the activation of RAAS in DKD results in renal tubular injury through inflammation, hypoxia, fibrosis, and altered sodium and water handling