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10.1021/acs.biochem.6b00622 39 ShuklaP.GoswamiS.KeizerR

Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases

Any dysfunction in this chain of events caused by lack of cofactors or mitochondrial dysfunction would lead to reduced ATP formation and increased ROS, Ca 2+ and long chain fatty acid acyls and acylcarnitine buildup