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It has been reported that sorafenib can induce ferroptosis in tumor cells through the p62-kelch-like ECH-associated protein 1-NRF2 pathway to achieve anti-tumor efficacy (33)

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J Clin Endocriol Metab

3 The most common adverse events reported with Trulicity include nausea, diarrhea and vomiting and were reported more frequently than with placebo-treated patients