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Jahan-Mihan et al., The role of altered levels of GLP-1 and PYY in the pathogenesis of diseases such as diabetes, obesity and non-alcoholic fatty liver diseases has been suggested and understanding the mechanisms of their release and regulation, might greatly contribute to the development of therapeutics (Valassi et al., 2009)

doi:10.1001/jama.2021.1831 10.A Research Study to See How Semaglutide Helps People With Excess Weight, Lose Weight (STEP UP) (STEP UP)

Investigators reported A1C reductions of 1.7% to 2.0% across doses at 40 weeks