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Nausea management strategies: - Start at 1 mg rather than 1.75 mg for the first dose - Take ondansetron (Zofran) 30 minutes before injection - Eat a light meal 1 to 2 hours before dosing - BPC-157 at 250 to 500 mcg may reduce nausea (anecdotal, not clinically validated for this use) Contraindications: uncontrolled hypertension, pregnancy, significant hepatic impairment

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6 control and 6 cKOt mice at each point, sacrificed at 6 different Zeitgeber time points: ZT0, ZT4, ZT8, ZT12, ZT16, and ZT20 (with ZT0 and ZT12 corresponding to times when light is switched on and off, respectively)