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Where to Inject Semaglutide in the Leg If youre choosing your leg for your semaglutide injections, you want to make sure youre following these guidelines: Inject into the fatty area on the front or outer side of your upper thigh, closer to your hip than your knee Avoid the inner thigh Avoid injecting directly into the muscle or vein Where to Inject Semaglutide in the Arm The upper arm is another popular semaglutide injection site