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At position 204, A is the most frequent nucleotide for subtype 1a clade I, whereas C is the most frequent nucleotide for subtype 1a clade II, and C or T are the most frequent nucleotides for subtype 1b

This leads to an interesting hypothesis, i.e., early in infection, the coatomer sequesters the S protein near ERGIC to provide a window for the assembly of infectious progeny virions, prior to S export to PM at a later stage for cell-cell fusion and virion transmission

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Q4: Could NAD+ supplement side effects include creating a metabolic dependency?: Not in a biological sense