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Recently, neural activity mediated by NMDA-receptors (NMDAR) has been coupled with transcriptional activation of glutamate-cysteine ligase, a key enzyme in GSH production, leading to a sustained GSH-based protection against an oxidative insult 26

OPG and RANK/RANKL expression could be upregulated with increased catabolism in AF, NP, or CEP cells exposed to acidic microenvironments or the inflammatory factor IL-1 (63, 64)

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The first and second approaches have another problem: the same fruit cultivar could be tested twice with different results