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Induction in certain studies was mainly mediated by Nrf-2 agonists, such as curcumin and resveratrol (62,63)

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Other pharmacological options include catechol-O-methyltransferase (COMT) inhibitors like entacapone and opicapone, which extend the half-life of levodopa, do not cross the BBB at all and primarily affect peripheral metabolism, providing no direct action in the brain 59