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We selected CD5/ LNPs because CD5 is expressed by T cells but is not required for T cell effector function 46,50
So, I think its important to let patients know that we as their clinicians are being watchful for the potential emergence of side effects and that we can do things about them
Exenatide (EC 50 = 0.60 nM, E max = 125%) and liraglutide (EC 50 = 1.8 nM, E max = 117%) were 380- and 130-fold more potent, respectively, and caused somewhat greater receptor internalization relative to PF-06882961 (Table S5)
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