The most common side effects of oral silymarin ingestion include:2 Abdominal pain/fullness Bloating Bowel changes Diarrhea Dyspepsia (indigestion) Flatulence Headache Nausea Pruritus (itching) Of note, there's at least one case report of more severe instances of the above, along with sweating, colicky pain, weakness, and collapse, in a 57-year-old woman after taking a milk thistle capsule
These thresholds align with clinical evidence showing meaningful metabolic and cardiovascular benefits at these body weight levels
Although some studies investigated the relationship between ghrelin or GLP-1 and behavioral motivation (e.g., Willingness to pay, Rihm et al., 2019
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