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Even brief exposure to high heat causes rapid degradation that cannot be reversed by returning the vial to the fridge

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Ive got to do that because otherwise I somehow cheated myself, Winfrey said in September 2023 during a panel on Oprah Daily, called The State of Weight. It was after that discussion that she changed her mind about using a weight-loss drug, Winfrey told People, calling it her "biggest aha" moment: I realized Id been blaming myself all these years for being overweight, and I have a predisposition that no amount of willpower is going to control. Frustration with her weight has occupied five decades of space" in her brain, she noted

These medications can be expensive without coverage, often costing hundreds to over a thousand dollars per month