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It points to GLP-1 receptors being stimulated throughout the body, including in the brain's appetite and nausea centers, and says that widespread activation combines with rapid changes in blood glucose and hydration status during early treatment

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Role of alpha-cell GLP-1 production in metabolic dysfunction Alpha-cell GLP-1 production as an adaptive response to metabolic dysfunction Although the in vivo physiological function of intra-islet GLP-1 has been questioned since levels of GLP-1 in the pancreas of healthy mice are considerably low and sometimes undetected (5, 83), metabolic stress has been reported to potently increase alpha-cell-derived GLP-1 and decrease L-cell-derived GLP-1 in rodents and humans (18, 58, 8490)