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Important Considerations for Combining NAD+ and AOD9604 Despite the theoretical appeal, several crucial points must be considered when exploring the combination of NAD+ and AOD9604: Lack of Direct Combined Research: The most significant caveat is the current lack of extensive human clinical trials specifically investigating the combined effects of NAD+ precursors and AOD9604

As we age, NAD+ levels naturally decline, which has been linked to various age-related diseases, including neurodegenerative disorders, cardiovascular diseases, and metabolic dysfunction

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SCFAs exist mainly in the intestine in the anionic (98%) and dissociated (2%) forms (Friederike, 2018)