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So someone can have a strong family history, metabolic dysfunction, discordantly high apoB, early scans suggesting disease, and a high risk cumulative exposure picture and still look "low risk" in a short-term model due to their age

There is substantial evidence that insulin/IGF-1 signaling stimulates the expansion of Tregs and increases their immunosuppressive activity [28, 34]

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Weight loss which exceeds what is expected in an older adult treated with GLP-1 receptor agonist should be investigated to exclude malignancy