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c , Protein levels from cancer cell lines from DepMaps CCLE (Proteomics GGT1: P19440 (n = 339), GGT5: P36269 (n = 108), GGT6: Q6P531 (n = 45), GGT7: Q9UJ14 (n = 375))

Preliminary studies have shown that targeting GLO1 by small molecule inhibitors such as S-p-bromobenzylglutathione cyclopentyl diester (BBGC) significantly inhibits the growth and induces apoptosis of leukemia and other tumor cells, while reversing the resistance of cancer cells to chemotherapeutic drugs (103, 144, 152154)