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GI problems involve Crohns disease, reflux, esophagus cancer, and other disorders (Bhattacharyya et al

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Although they primarily target joints, central nervous system, gastrointestinal tract, and multiple systemic organs, respectively, a common hallmark across these diseases is a significant disruption in the balance of T cell subsets, particularly a dynamic imbalance between Th17 cells and Treg cells ( Figure 2 )

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