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Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

people at higher risk of deficiency include older adults, those with gastrointestinal issues that impair absorption, people whove had gastric surgery, long-term strict vegans who do not supplement, and those on certain acid-reducing medicines

SAM supplies methyl groups for hundreds of reactions involving DNA, phospholipids, neurotransmitter metabolism, creatine synthesis, hormone metabolism and selected detoxification reactions

It is primarily marketed and sold for research purposes only, and its regulatory status indicates that it is not regulated by the FDA or similar bodies for human use