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These medications work by increasing feelings of fullness by slowing the rate at which the stomach empties, which can help reduce the urge to overeat

In the trials, different groups were assigned different target doses (1, 4, 8, or 12 mg), and the increase was paused or slowed if a person had side effects

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The GLP-1 peptide found in all other mammalian species binds the human GLP-1R with an IC50 of 7.9 10 10 M (Table 2), whereas the monotreme GLP-1 peptides bind the human and platypus GLP-1R with 50 fold lower affinity