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Infection and Immunity, 66 (12), 56205629

This chapter will refer to primary or acute effects as those effects that begin within the first minutes after injury, secondary or subacute effects as those that arise over the next 24 hours after injury, and long-term or chronic effects as those that are associated with the insult but occur at a later time

Early reports that Kupffer cell-induced oxidant stress and peroxynitrite formation may cause APAP-induced injury [92, 93] were questioned as the data could not be reproduced [9496], NADPH oxidase-deficient mice were not protected [97, 98] and mitochondria in centrilobular hepatocytes were identified as the main source of superoxide and peroxynitrite under these conditions [72, 99]

The following adverse reactions have been identified during postapproval use of ADVATE