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810), with complete datasets available in Supplementary Tables 910

The Lau monotherapy data cuts through that by showing the amylin analog producing double-digit weight loss entirely on its own, which is the cleanest argument that adding it to a triple agonist brings genuinely additive firepower rather than redundant signalling

A inhibits the activity of key mitochondrial enzymes such as electron transport chain enzyme complex IV, pyruvate dehydrogenase (PDH), and -ketoglutarate dehydrogenase (KGDH), reducing the efficiency of electron transfer, diminishing ATP synthesis, and stimulating the production of ROS

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