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The functional GDH is a hexamer structure composed of two sets of trimers, with each trimer containing ~ 500 amino acids and each monomer possessing a guanosine triphosphate (GTP) binding site and a nicotinamide adenine diphosphate hydride (NADH)/adenosine diphosphate (ADP) binding site, enabling binding of 6 GTP molecules, 6 ADP molecules and 6 NADH molecules with GDH hexamer at its respective allosteric binding sites

Low Risk of Hypoglycemia: Safe for use due to their glucose-dependent mechanism

Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines

There were 91 out of 98 (93%) patients previously treated prophylactically prior to enrollment, who experienced a reduction in dosing frequency during routine prophylaxis in the trial, with a median reduction of 33.7% (approximately one more day between doses)