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Challenges Due to its well-established role in neural tube development, folic acid supplementation is recommended in clinical guidelines (US Preventive Services Task Force, American College of Obstetricians and Gynecologists, American Academy of Family Physicians, American Academy of Pediatrics, and the Center for Disease Control and Prevention) for those who are planning to or could become pregnant (Force et al., 2023)

Comprehensive evaluation helps identify contributing factors that need direct treatment

Mental Health and Depression DSIP appears to influence serotonin metabolism and monoamine oxidase activity, which are critical in mood regulation ( 8, 10 )

More Study Is Still Needed Even before research on alternative dosing schedules emerged, some clinicians were already experimenting with off-label adjustments to injection frequency