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CYP2D6, MDMA, and methamphetamine: background considerations CYP2D6 accounts for only a small percentage of total hepatic cytochrome P450 (12%), yet it is responsible for the metabolism of approximately 2030% of marketed pharmaceuticals, including tricyclic antidepressants, selective serotonin reuptake inhibitor antidepressants, opioids, and antipsychotic, antiemetic, antiarrhythmic, and amphetamine-like drugs (Ingelman-Sundberg, 2005)

Results and Discussion In pancreatic -cells, GLP-1 RAs regulate the secretion of insulin and glucagon in a glucosedependent manner by influencing signaling pathways such as cAMP, PI3K, and MAPK

A.et al (2010)

M., DeSilva, D., Pickart, L., & Aust, S