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(Scientific Reports, 2022) showed that the combination of 5-Amino-1MQ + caloric restriction establishes a distinct cecal microbial profile, normalizing the microbiome to the levels of lean control mice, whereas caloric restriction alone fails to do so

The extra weight leads to an increase in the NNMT enzyme, leading to slower fat metabolism, leading to excess weight gain

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The results of once daily administration of the peptide for 12 weeks showed that the drug tripled weight loss when compared to placebo and that the rate of weight loss remained steady during the trial period