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Current clinical studies have focused on adults living with obesity, as well as adults who are overweight and have additional weightrelated health conditions

Randomized controlled trials (RCTs), which is the gold-standard approach to extend indication of marketed drugs, have been limited by short follow-up periods and insufficient number of cases to detect the effect of GLP-1R agonists on ovarian cancer 15,16,17

Newly initiated GLP-1 users spent about 22 percent more in dollars during their first 1-3 months on therapy, while household grocery baskets contract by 4 to 6 percent over the first six months

3-5 Microbial metabolites, such as secondary bile acids, short-chain fatty acids, lipopolysaccharide and others within the gut microbiota, trigger GLP-1 secretion