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Patients can begin with semaglutide monotherapy and graduate to the dual compound if needed, creating a personalized escalation pathway

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Patients not treated with tirzepatide experienced major adverse cardiovascular events, including death, myocardial infarction, stroke, heart failure, arrhythmia, or intracerebral hemorrhage, 44% more frequently (HR 1.44, 95% CI 1.221.70)