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A meta-analysis was done which indicates that albiglutide is linked to a higher risk of early-stage DR compared to placebo, while showing a reduced risk of late-stage DR compared to insulin (85) Furthermore, the other six FDA-approved GLP-1RAs do not demonstrate a statistically significant association with DR

The best known are superoxide (O 2 - ) which is quenched by superoxide dismutase, hydrogen peroxide (H 2 O 2 ) which is removed by catalase and glutathione (GSH) peroxidase, and the highly reactive hydroxyl radical (OH ) - leaving aside products of interaction with nitric oxide (46, 87)

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Nasteska D, Harada N, Suzuki K, et al