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Still, psychiatrists like Georgios Schoretsanitis at the University of Zurich and Chiara Gastaldon at the University of Verona saw a need for additional analyses while the regulatory agencies were reviewing their own datasets

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Loading Dose When the time to reach steady state is appreciable, as it is for drugs with long half-lives, it may be desirable to administer a loading dose that promptly raises the concentration of drug in plasma to the target concentration