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Chronic antidepressants reduce depolarization-evoked glutamate release and protein interactions favoring formation of SNARE complex in hippocampus

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When the ligand binds to the extracellular domain of the receptor, the G-protein undergoes conformational change and GTP replaces the GDP on the -subunit

Transcriptomic profiling indicates regulation of cell proliferation and ECM formation after aloxistatin treatment To validate the impact of aloxistatin on HCF functionality, we investigated mRNA expression profiles upon Aloxistatin treatment in comparison to solvent control (DMSO) in ICM and DCM-derived HCFs