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C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe

Applying NAPstars, we find a surprisingly oxidised cytosolic NADP redox state albeit with a remarkable robustness to oxidative challenges in yeast, human cells and plant

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This review assesses its mechanisms and clinical evidence, while identifying critical research gaps to inform future therapeutic strategies for PD