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It stimulates two key metabolic receptors: GLP-1, like Wegovy GIP, which further enhances insulin control and weight-loss effects Because of this dual mechanism, clinical studies show patients may lose 20% or more of their body weight, making Zepbound one of the most powerful options available today

A significant reduction in epididymal fat mass was quantified at endpoint after RETA and reflected by an almost ablated concentration of circulating leptin, whereas after RETA withdrawal, white adipose mass and leptin concentrations were partially reversed compared to Veh (Fig