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The importance of individualised, holistic treatment in the context of complex clinical decisions was also highlighted by the lack of consensus regarding use of SGLT2is versus GLP-1 RAs in frailty, with differing preferences depending on specific risks or symptoms, requiring clinical judgement to balance efficacy and safety

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Thus, the incubations with DTT and diamide indicate a dynamic range of about five which is in line with another study using the same probe in the yeast cytosol (Morgan et al , 2011)

These adaptations can support survival and resistance to selected treatments, with effects varying by cell lineage, genotype, nutrient availability, and drug mechanism (Jyotsana et al., 2022)