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Thus, coronaviruses have the potential to induce tissue damage and end organ disease through viral replication, increased inflammation and apoptosis, induction of ROS and reduction of cytoprotective pathways such as the Nrf2 and HO-1 pathways

However, although the IBD itself is typically milder in IBD-PSC than in those with IBD alone [212], IBD-PSC is associated with a significantly increased risk of dysplasia and colorectal cancer compared to those with IBD alone [213]

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