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Stronger mechanistic clarification would require isoform-specific NOS inhibition, direct measurement of NO metabolites, eNOS phosphorylation analysis, rescue experiments, and comparison across endothelial, epithelial, fibroblast, and neuronal model systems

Regular follow-up appointments will ensure that the treatment is working effectively and allow any necessary adjustments to be made

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Exceeding recommended schedules or skipping required titration phases can rapidly overwhelm the GI tract, leading to severe dehydration, electrolyte imbalance, and secondary organ stress