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The SELECT trial's cardiovascular benefit data (20% MACE reduction) has been particularly influential in changing payer attitudes, because preventing heart attacks and strokes saves money long-term

By reducing visceral fat, lowering blood pressure, and improving vascular function, these medications may reduce the burden on the heart

In short GLP-1s can subtly dehydrate you without you realizing it

It can also cause seizures when mixed with some antipsychotics (or bupropion) and serotonin syndrome when combined with certain selective serotonin reuptake inhibitors (SSRIs)